Biological and chronological age5/18/2023 ![]() ![]() This means that how old someone seems or feels does not always match the number of years they have been alive in other words, someone’s “biological age” can often differ from their “chronological age”. In joint models, two methylation age estimators (Horvath and GrimAge) and FI remained predictive, suggesting they are complementary in predicting mortality.Īging biological age correlation epidemiology global health human longitudinal trajectory mortality.Įveryone ages, but how aging affects health varies from person to person. The largest effects were seen for methylation age estimators (GrimAge) and the frailty index (FI). Individually, all BAs except for telomere length were associated with mortality risk independently of CA. All BAs were correlated to varying degrees correlations were mostly explained by CA. We found the longitudinal growth of functional BAs accelerated around age 70 average levels of BA curves differed by sex across the age span (50-90 years). We included 845 individuals and 3973 repeated measurements from a Swedish population-based cohort and examined longitudinal trajectories, correlations, and mortality associations of nine BAs across 20 years follow-up. Multiple BAs have been proposed and are well studied individually but not jointly. Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological age (CA).
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